Sample size requirement in trials that use the composite endpoint major adverse cardiovascular events (MACE): new insights

Sample size requirement in trials that use the composite endpoint major adverse cardiovascular events (MACE): new insights

Abstract Background The real impact of the degree of association (DoA) between endpoint components of a composite endpoint (CE) on sample size requirement (SSR) has not been explored. We estimate the impact of the DoA between death and acute myocardial infarction (AMI) on SSR of trials using use the...

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Bibliographic Details
Main Authors: Josep Ramon Marsal, Iratxe Urreta-Barallobre, Marimar Ubeda-Carrillo, Dimelza Osorio, Blanca Lumbreras, David Lora, Borja M. Fernández-Felix, Gerard Oristrell, Eduard Ródenas-Alesina, Lorena Herrador, Mónica Ballesteros, Javier Zamora, Jose I. Pijoan, Aida Ribera, Ignacio Ferreira-González
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Trials
Subjects:
Composite endpoints
Sample size
Correlation
MACE
Online Access:https://doi.org/10.1186/s13063-022-06977-4

Internet

https://doi.org/10.1186/s13063-022-06977-4

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