IL-4Rα signalling in B cells and T cells play differential roles in acute and chronic atopic dermatitis

Abstract Atopic dermatitis (AD) is a common pruritic inflammatory skin disease with complex environmental and genetic predisposing factors. Primary skin barrier dysfunction and aberrant T helper 2 (TH2) responses to common allergens, together with increased serum IgE antibodies, characterise the dis...

Полное описание

Библиографические подробности
Главные авторы: Martyna Scibiorek, Nontobeko Mthembu, Sandisiwe Mangali, Amkele Ngomti, Paul Ikwegbue, Frank Brombacher, Sabelo Hadebe
Формат: Статья
Язык:English
Опубликовано: Nature Portfolio 2023-01-01
Серии:Scientific Reports
Online-ссылка:https://doi.org/10.1038/s41598-022-26637-6