Identification of Molecular Determinants in iRhoms1 and 2 That Contribute to the Substrate Selectivity of Stimulated ADAM17

Identification of Molecular Determinants in iRhoms1 and 2 That Contribute to the Substrate Selectivity of Stimulated ADAM17

The metalloprotease ADAM17 is a key regulator of the TNFα, IL-6R and EGFR signaling pathways. The maturation and function of ADAM17 is controlled by the seven-membrane-spanning proteins iRhoms1 and 2. The functional properties of the ADAM17/iRhom1 and ADAM17/iRhom2 complexes differ, in that stimulat...

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Bibliographic Details
Main Authors: Yi Zhao, Eliud Morales Dávila, Xue Li, Beiyu Tang, Ariana I. Rabinowitsch, Jose Manuel Perez-Aguilar, Carl P. Blobel
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:International Journal of Molecular Sciences
Subjects:
ADAM17 (a disintegrin and metalloprotease 17)
iRhom1 and 2 (inactive rhomboid like protein 1 and 2)
EGFR-ligand (epidermal growth factor receptor ligand)
protein ectodomain shedding
Online Access:https://www.mdpi.com/1422-0067/23/21/12796

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https://www.mdpi.com/1422-0067/23/21/12796

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