Endogenous TRAIL-R4 critically impacts apoptotic and non-apoptotic TRAIL-induced signaling in cancer cells

Endogenous TRAIL-R4 critically impacts apoptotic and non-apoptotic TRAIL-induced signaling in cancer cells

Binding of TRAIL to its death domain-containing receptors TRAIL-R1 and TRAIL-R2 can induce cell death and/or pro-inflammatory signaling. The importance of TRAIL and TRAIL-R1/R2 in tumor immune surveillance and cancer biology has meanwhile been well documented. In addition, TRAIL has been shown to pr...

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Bibliographic Details
Main Authors: Anna-Christina Rambow, Insa Aschenbach, Sofie Hagelund, Doaa Tawfik, Jan-Paul Gundlach, Sebastian Weiße, Nicolai Maass, Anna Trauzold
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
TRAIL-R4
TRAIL
apoptosis
non-apoptotic signaling
pancreatic cancer
breast cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.942718/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2022.942718/full

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