Endoplasmic reticulum stress in melanoma pathogenesis and resistance
Melanoma is the most lethal skin cancer with rising incidence worldwide. Despite significant advances in target therapy and immunotherapy, low response rates and the development of drug resistance remain key clinical barriers affecting patient prognosis. The complex interplay between multiple signal...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-11-01
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| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332222011301 |
| _version_ | 1798030964211843072 |
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| author | Yi Kong Jian Jiang Yuqiong Huang Li Li Xin Liu Zilin Jin Fen Wei Xinxin Liu Song Zhang Xiaoru Duan Yonghui Zhang Qingyi Tong Hongxiang Chen |
| author_facet | Yi Kong Jian Jiang Yuqiong Huang Li Li Xin Liu Zilin Jin Fen Wei Xinxin Liu Song Zhang Xiaoru Duan Yonghui Zhang Qingyi Tong Hongxiang Chen |
| author_sort | Yi Kong |
| collection | DOAJ |
| description | Melanoma is the most lethal skin cancer with rising incidence worldwide. Despite significant advances in target therapy and immunotherapy, low response rates and the development of drug resistance remain key clinical barriers affecting patient prognosis. The complex interplay between multiple signaling molecules and pathways has brought little understanding of melanoma pathogenesis and resistance. The genetic mutation and hypermetabolic environment of melanoma cells lead to increasing demands for protein synthesis and perturb proteostasis resulting in endoplasmic reticulum (ER) stress. Subsequently, three unfolded protein response (UPR) signaling branches, represented by IRE1α, PERK and ATF6, are activated to direct cell fate towards pro-survival or pro-apoptosis depending on the intensity and duration of ER stress. In this review, we summarize ER stress and UPR in melanoma cells and tumor-infiltrating immune cells along with the crosstalk among these pathways. We provide the latest advances in understanding melanoma pathogenesis and resistance and discuss the potential of targeting the ER stress or UPR process for melanoma therapy. |
| first_indexed | 2024-04-11T19:49:41Z |
| format | Article |
| id | doaj.art-df9e89dfeb78410abf4d118a2f0e8a26 |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-04-11T19:49:41Z |
| publishDate | 2022-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-df9e89dfeb78410abf4d118a2f0e8a262022-12-22T04:06:21ZengElsevierBiomedicine & Pharmacotherapy0753-33222022-11-01155113741Endoplasmic reticulum stress in melanoma pathogenesis and resistanceYi Kong0Jian Jiang1Yuqiong Huang2Li Li3Xin Liu4Zilin Jin5Fen Wei6Xinxin Liu7Song Zhang8Xiaoru Duan9Yonghui Zhang10Qingyi Tong11Hongxiang Chen12Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Road No.1277, Wuhan, Hubei Province 430022, ChinaDepartment of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Road No.1277, Wuhan, Hubei Province 430022, ChinaDepartment of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Road No.1277, Wuhan, Hubei Province 430022, ChinaDepartment of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Road No.1277, Wuhan, Hubei Province 430022, ChinaDepartment of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Road No.1277, Wuhan, Hubei Province 430022, ChinaDepartment of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Road No.1277, Wuhan, Hubei Province 430022, ChinaDepartment of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Road No.1277, Wuhan, Hubei Province 430022, ChinaDepartment of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Road No.1277, Wuhan, Hubei Province 430022, ChinaDepartment of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Road No.1277, Wuhan, Hubei Province 430022, ChinaDepartment of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Road No.1277, Wuhan, Hubei Province 430022, ChinaHubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji-Rongcheng Center for Biomedicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China; Corresponding authors.Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji-Rongcheng Center for Biomedicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China; Corresponding authors.Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Road No.1277, Wuhan, Hubei Province 430022, China; Department of Dermatology, Union Shenzhen Hospital, Huazhong University of Science and Technology, 518052, Shenzhen, China; Corresponding author at: Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Road No.1277, Wuhan, Hubei Province 430022, China.Melanoma is the most lethal skin cancer with rising incidence worldwide. Despite significant advances in target therapy and immunotherapy, low response rates and the development of drug resistance remain key clinical barriers affecting patient prognosis. The complex interplay between multiple signaling molecules and pathways has brought little understanding of melanoma pathogenesis and resistance. The genetic mutation and hypermetabolic environment of melanoma cells lead to increasing demands for protein synthesis and perturb proteostasis resulting in endoplasmic reticulum (ER) stress. Subsequently, three unfolded protein response (UPR) signaling branches, represented by IRE1α, PERK and ATF6, are activated to direct cell fate towards pro-survival or pro-apoptosis depending on the intensity and duration of ER stress. In this review, we summarize ER stress and UPR in melanoma cells and tumor-infiltrating immune cells along with the crosstalk among these pathways. We provide the latest advances in understanding melanoma pathogenesis and resistance and discuss the potential of targeting the ER stress or UPR process for melanoma therapy.http://www.sciencedirect.com/science/article/pii/S0753332222011301MelanomaER stressUPRIRE1PERKATF6 |
| spellingShingle | Yi Kong Jian Jiang Yuqiong Huang Li Li Xin Liu Zilin Jin Fen Wei Xinxin Liu Song Zhang Xiaoru Duan Yonghui Zhang Qingyi Tong Hongxiang Chen Endoplasmic reticulum stress in melanoma pathogenesis and resistance Biomedicine & Pharmacotherapy Melanoma ER stress UPR IRE1 PERK ATF6 |
| title | Endoplasmic reticulum stress in melanoma pathogenesis and resistance |
| title_full | Endoplasmic reticulum stress in melanoma pathogenesis and resistance |
| title_fullStr | Endoplasmic reticulum stress in melanoma pathogenesis and resistance |
| title_full_unstemmed | Endoplasmic reticulum stress in melanoma pathogenesis and resistance |
| title_short | Endoplasmic reticulum stress in melanoma pathogenesis and resistance |
| title_sort | endoplasmic reticulum stress in melanoma pathogenesis and resistance |
| topic | Melanoma ER stress UPR IRE1 PERK ATF6 |
| url | http://www.sciencedirect.com/science/article/pii/S0753332222011301 |
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