Role of Farnesoid X Receptor and Bile Acids in Hepatic Tumor Development

Role of Farnesoid X Receptor and Bile Acids in Hepatic Tumor Development

Hepatocellular carcinoma (HCC) is a leading cause of cancer deaths worldwide, and an association between altered bile acid (BA) metabolism, down‐regulation of farnesoid X receptor (FXR), which is a master regulator of BA metabolism, and hepatocarcinogenesis has been documented. While global FXR defi...

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Bibliographic Details
Main Authors: Shogo Takahashi, Naoki Tanaka, Tatsuki Fukami, Cen Xie, Tomoki Yagai, Donghwan Kim, Thomas J. Velenosi, Tingting Yan, Kristopher W. Krausz, Moshe Levi, Frank J. Gonzalez
Format: Article
Language:English
Published: Wolters Kluwer Health/LWW 2018-12-01
Series:Hepatology Communications
Online Access:https://doi.org/10.1002/hep4.1263

Internet

https://doi.org/10.1002/hep4.1263

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