Arglabin, an EGFR receptor tyrosine kinase inhibitor, suppresses proliferation and induces apoptosis in prostate cancer cells

Arglabin, an EGFR receptor tyrosine kinase inhibitor, suppresses proliferation and induces apoptosis in prostate cancer cells

Evidence for clinical efficacy of a semisynthetic derivative of arglabin in anticancer treatment prompted us to examine molecular mechanisms and cellular targets of arglabin. Arglabin, a sesquiterpene lactone isolated from Artemisia glabella was cytotoxic to different human cancer cell lines includi...

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Bibliographic Details
Main Authors: Menna El Gaafary, Samy A.F. Morad, Michael Schmiech, Tatiana Syrovets, Thomas Simmet
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Sesquiterpene lactone
Receptor tyrosine kinase (RTK)
mTOR
Apoptosis
Thiol adducts
F-actin
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332222012628

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http://www.sciencedirect.com/science/article/pii/S0753332222012628

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