Overcoming T cell dysfunction in acidic pH to enhance adoptive T cell transfer immunotherapy

Overcoming T cell dysfunction in acidic pH to enhance adoptive T cell transfer immunotherapy

The high metabolic activity and insufficient perfusion of tumors leads to the acidification of the tumor microenvironment (TME) that may inhibit the antitumor T cell activity. We found that pharmacological inhibition of the acid loader chloride/bicarbonate anion exchanger 2 (Ae2), with 4,4’-diisothi...

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Bibliographic Details
Main Authors: Flor Navarro, Noelia Casares, Celia Martín-Otal, Aritz Lasarte-Cía, Marta Gorraiz, Patricia Sarrión, Diana Llopiz, David Reparaz, Nerea Varo, Juan Roberto Rodriguez-Madoz, Felipe Prosper, Sandra Hervás-Stubbs, Teresa Lozano, Juan José Lasarte
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:OncoImmunology
Subjects:
Lymphocytes
intracellular pH
tumor microenvironment
AE2
HVCN1
adoptive cell therapy
Online Access:https://www.tandfonline.com/doi/10.1080/2162402X.2022.2070337

Internet

https://www.tandfonline.com/doi/10.1080/2162402X.2022.2070337

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