Conserved Induction of Distinct Antiviral Signalling Kinetics by Primate Interferon Lambda 4 Proteins

Conserved Induction of Distinct Antiviral Signalling Kinetics by Primate Interferon Lambda 4 Proteins

Interferon lambdas (IFNλ) (also known as type III IFNs) are critical cytokines that combat infection predominantly at barrier tissues, such as the lung, liver, and gastrointestinal tract. Humans have four IFNλs (1–4), where IFNλ1–3 show ~80%–95% homology, and IFNλ4 is the most divergent displaying o...

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Bibliographic Details
Main Authors: Cuncai Guo, Dorothee Reuss, Jonathon D. Coey, Swathi Sukumar, Benjamin Lang, John McLauchlan, Steeve Boulant, Megan L. Stanifer, Connor G. G. Bamford
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Immunology
Subjects:
interferon
lambda
signalling
antiviral
IFNL4
kinetics
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.772588/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.772588/full

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