Integration of bulk RNA sequencing and single-cell analysis reveals a global landscape of DNA damage response in the immune environment of Alzheimer’s disease

Integration of bulk RNA sequencing and single-cell analysis reveals a global landscape of DNA damage response in the immune environment of Alzheimer’s disease

BackgroundWe developed a novel system for quantifying DNA damage response (DDR) to help diagnose and predict the risk of Alzheimer’s disease (AD).MethodsWe thoroughly estimated the DDR patterns in AD patients Using 179 DDR regulators. Single-cell techniques were conducted to validate the DDR levels...

Full description

Bibliographic Details
Main Authors: Yongxing Lai, Han Lin, Manli Chen, Xin Lin, Lijuan Wu, Yinan Zhao, Fan Lin, Chunjin Lin
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Immunology
Subjects:
DNA damage response
single-cell
Alzheimer’s disease
molecular subtypes
machine learning
immunity
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1115202/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1115202/full

Similar Items