Human CAP cells represent a novel source for functional, miRNA-loaded exosome production.

Exosomes represent a promising delivery tool for nucleic acid-based pharmaceuticals. They are highly suitable for transporting therapeutic miRNAs to tumor cells, due to their natural membrane components. Further, exosomes are capable of effectively protecting nucleic acids against ribonucleases and...

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Bibliographic Details
Main Authors: Nikolas Zeh, Helga Schneider, Sven Mathias, Nadja Raab, Michael Kleemann, Sabine Schmidt-Hertel, Benjamin Weis, Silke Wissing, Nikola Strempel, René Handrick, Kerstin Otte
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0221679