mTOR regulates T cell exhaustion and PD-1–targeted immunotherapy response during chronic viral infection
T cell exhaustion is a state of T cell dysfunction associated with expression of programmed death 1 (PD-1). Exhausted CD8+ T cells are maintained by self-renewing stem-like T cells that provide differentiated TIM3+ cells, a part of which possesses effector-like properties. PD-1–targeted therapies en...
| मुख्य लेखकों: | , , , , , , , , , , , |
|---|---|
| स्वरूप: | लेख |
| भाषा: | English |
| प्रकाशित: |
American Society for Clinical Investigation
2023-01-01
|
| श्रृंखला: | The Journal of Clinical Investigation |
| विषय: | |
| ऑनलाइन पहुंच: | https://doi.org/10.1172/JCI160025 |