Elastomeric Pillar Cages Modulate Actomyosin Contractility of Epithelial Microtissues by Substrate Stiffness and Topography

Elastomeric Pillar Cages Modulate Actomyosin Contractility of Epithelial Microtissues by Substrate Stiffness and Topography

Cell contractility regulates epithelial tissue geometry development and homeostasis. The underlying mechanobiological regulation circuits are poorly understood and experimentally challenging. We developed an elastomeric pillar cage (EPC) array to quantify cell contractility as a mechanoresponse of e...

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Bibliographic Details
Main Authors: Lisann Esser, Ronald Springer, Georg Dreissen, Lukas Lövenich, Jens Konrad, Nico Hampe, Rudolf Merkel, Bernd Hoffmann, Erik Noetzel
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Cells
Subjects:
mechanosensing
mechanotransduction
cell force measurement
cell-matrix adhesion
cell-cell adhesion
actomyosin
Online Access:https://www.mdpi.com/2073-4409/12/9/1256

Internet

https://www.mdpi.com/2073-4409/12/9/1256

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