Smooth muscle liver kinase B1 inhibits foam cell formation and atherosclerosis via direct phosphorylation and activation of SIRT6

Smooth muscle liver kinase B1 inhibits foam cell formation and atherosclerosis via direct phosphorylation and activation of SIRT6

Abstract Foam cell formation is a hallmark of the early phase of atherosclerosis. Growing evidence has demonstrated that vascular smooth muscle cells (VSMCs) comprise a considerable proportion of foam cells. Liver kinase B1 (LKB1) plays a crucial part in cardiovascular diseases. However, the role of...

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Bibliographic Details
Main Authors: Qiming Deng, Hongxuan Li, Xiaolin Yue, Chenghu Guo, Yuanyuan Sun, Chang Ma, Jiangang Gao, Yue Wu, Bin Du, Jianmin Yang, Cheng Zhang, Wencheng Zhang
Format: Article
Language:English
Published: Nature Publishing Group 2023-08-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-023-06054-x

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https://doi.org/10.1038/s41419-023-06054-x

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