A combined high-throughput and high-content platform for unified on-chip synthesis, characterization and biological screening
On-chip synthesis and screening has been used to automate drug discovery but on-chip analysis still remains a major limitation. Here, the authors report on a dendrimer-based surface patterning method to create nanodroplet arrays on materials which allow for on-chip high-throughput analysis.
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-19040-0 |
| _version_ | 1819129752937562112 |
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| author | Maximilian Benz Arndt Asperger Meike Hamester Alexander Welle Stefan Heissler Pavel A. Levkin |
| author_facet | Maximilian Benz Arndt Asperger Meike Hamester Alexander Welle Stefan Heissler Pavel A. Levkin |
| author_sort | Maximilian Benz |
| collection | DOAJ |
| description | On-chip synthesis and screening has been used to automate drug discovery but on-chip analysis still remains a major limitation. Here, the authors report on a dendrimer-based surface patterning method to create nanodroplet arrays on materials which allow for on-chip high-throughput analysis. |
| first_indexed | 2024-12-22T08:48:43Z |
| format | Article |
| id | doaj.art-dfad5ffb04194c0ab15d26319b74982c |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-22T08:48:43Z |
| publishDate | 2020-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-dfad5ffb04194c0ab15d26319b74982c2022-12-21T18:32:02ZengNature PortfolioNature Communications2041-17232020-10-0111111010.1038/s41467-020-19040-0A combined high-throughput and high-content platform for unified on-chip synthesis, characterization and biological screeningMaximilian Benz0Arndt Asperger1Meike Hamester2Alexander Welle3Stefan Heissler4Pavel A. Levkin5Karlsruhe Institute of Technology (KIT), Institute of Biological and Chemical Systems-Functional Molecular Systems (IBCS-FMS)Bruker Daltonik GmbHBruker Daltonik GmbHKarlsruhe Institute of Technology (KIT), Institute of Functional Interfaces (IFG)Karlsruhe Institute of Technology (KIT), Institute of Functional Interfaces (IFG)Karlsruhe Institute of Technology (KIT), Institute of Biological and Chemical Systems-Functional Molecular Systems (IBCS-FMS)On-chip synthesis and screening has been used to automate drug discovery but on-chip analysis still remains a major limitation. Here, the authors report on a dendrimer-based surface patterning method to create nanodroplet arrays on materials which allow for on-chip high-throughput analysis.https://doi.org/10.1038/s41467-020-19040-0 |
| spellingShingle | Maximilian Benz Arndt Asperger Meike Hamester Alexander Welle Stefan Heissler Pavel A. Levkin A combined high-throughput and high-content platform for unified on-chip synthesis, characterization and biological screening Nature Communications |
| title | A combined high-throughput and high-content platform for unified on-chip synthesis, characterization and biological screening |
| title_full | A combined high-throughput and high-content platform for unified on-chip synthesis, characterization and biological screening |
| title_fullStr | A combined high-throughput and high-content platform for unified on-chip synthesis, characterization and biological screening |
| title_full_unstemmed | A combined high-throughput and high-content platform for unified on-chip synthesis, characterization and biological screening |
| title_short | A combined high-throughput and high-content platform for unified on-chip synthesis, characterization and biological screening |
| title_sort | combined high throughput and high content platform for unified on chip synthesis characterization and biological screening |
| url | https://doi.org/10.1038/s41467-020-19040-0 |
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