Emerging Roles of Protease-Activated Receptors (PARs) in the Modulation of Synaptic Transmission and Plasticity

Emerging Roles of Protease-Activated Receptors (PARs) in the Modulation of Synaptic Transmission and Plasticity

Protease-activated receptors (PARs) are a class of G protein-coupled receptors (GPCRs) with a unique mechanism of activation, prompted by a proteolytic cleavage in their N-terminal domain that uncovers a tethered ligand, which binds and stimulates the same receptor. PARs subtypes (PAR1-4) have well-...

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Bibliographic Details
Main Authors: Rachel Price, Nicola Biagio Mercuri, Ada Ledonne
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:International Journal of Molecular Sciences
Subjects:
protease-activated receptors
serine proteases
matrix metalloproteases
glutamate
GABA
synaptic transmission
Online Access:https://www.mdpi.com/1422-0067/22/2/869

Internet

https://www.mdpi.com/1422-0067/22/2/869

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