FOXO3 regulates a common genomic program in aging and glioblastoma stem cells

FOXO3 regulates a common genomic program in aging and glioblastoma stem cells

Abstract Background Glioblastoma (GBM) is an aggressive, age‐associated malignant glioma that contains populations of cancer stem cells. These glioma stem cells (GSCs) evade therapeutic interventions and repopulate tumors due to their existence in a slowly cycling quiescent state. Although aging is...

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Bibliographic Details
Main Authors: Amanda J. Audesse, Galina Karashchuk, Zachary A. Gardell, Nelli S. Lakis, Sun Y. Maybury‐Lewis, Abigail K. Brown, Dena S. Leeman, Yee Voan Teo, Nicola Neretti, Douglas C. Anthony, Alexander S. Brodsky, Ashley E. Webb
Format: Article
Language:English
Published: Wiley 2021-12-01
Series:Aging and Cancer
Subjects:
aging
glioma
stem cells
transcriptomics
Online Access:https://doi.org/10.1002/aac2.12043

Internet

https://doi.org/10.1002/aac2.12043

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