Alternative forms of selectivity filters and turrets, and the patterning of cysteines in extended loops provide clues to a unique extracellular domain within eukaryotic voltage-gated sodium, calcium, and NALCN channels
How nature discriminates sodium from calcium ions in eukaryotic channel pores has been difficult to resolve because these are asymmetrical pores, contributed by four different homologous domains. Alternatively spliced pores in invertebrate homologs provide insights into different structural feature...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2015-05-01
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| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fphys.2015.00153/full |