Layer-specific cholinergic control of human and mouse cortical synaptic plasticity

Nicotinic acetylcholine receptors (nAChRs) are differentially expressed across cortical layers, yet it is unclear whether they show layer-specific effects on synaptic plasticity in the prefrontal cortex. Here, the authors compare nAChRs across L6 and L2/3 in human and mouse cortex and find they medi...

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Bibliographic Details
Main Authors: Matthijs B. Verhoog, Joshua Obermayer, Christian A. Kortleven, René Wilbers, Jordi Wester, Johannes C. Baayen, Christiaan P. J. De Kock, Rhiannon M. Meredith, Huibert D. Mansvelder
Format: Article
Language:English
Published: Nature Portfolio 2016-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms12826