Development of Novel Patient-Derived Xenografts from Breast Cancer Brain Metastases

Development of Novel Patient-Derived Xenografts from Breast Cancer Brain Metastases

Brain metastases are an increasing burden among breast cancer patients, particularly for those with HER2+ and triple negative (TN) subtypes. Mechanistic insight into the pathophysiology of brain metastases and preclinical validation of therapies has relied almost exclusively on intracardiac injectio...

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Bibliographic Details
Main Authors: María J. Contreras-Zárate, D. Ryan Ormond, Austin E. Gillen, Colton Hanna, Nicole L. Day, Natalie J. Serkova, Britta M. Jacobsen, Susan M. Edgerton, Ann D. Thor, Virginia F. Borges, Kevin O. Lillehei, Michael W. Graner, Peter Kabos, Diana M. Cittelly
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-11-01
Series:Frontiers in Oncology
Subjects:
patient-derived xenograft
brain metastases models
breast cancer
brain colonization
triple negative
HER2+
Online Access:http://journal.frontiersin.org/article/10.3389/fonc.2017.00252/full

Internet

http://journal.frontiersin.org/article/10.3389/fonc.2017.00252/full

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