Wildtype heterogeneity contributes to clonal variability in genome edited cells

Wildtype heterogeneity contributes to clonal variability in genome edited cells

Abstract Genome editing tools such as CRISPR/Cas9 enable the rapid and precise manipulation of genomes. CRISPR-based genome editing has greatly simplified the study of gene function in cell lines, but its widespread use has also highlighted challenges of reproducibility. Phenotypic variability among...

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Bibliographic Details
Main Authors: Lukas Westermann, Yong Li, Burulca Göcmen, Matthias Niedermoser, Kilian Rhein, Johannes Jahn, Isabel Cascante, Felix Schöler, Niklas Moser, Björn Neubauer, Alexis Hofherr, Yvonne Lisa Behrens, Gudrun Göhring, Anna Köttgen, Michael Köttgen, Tilman Busch
Format: Article
Language:English
Published: Nature Portfolio 2022-10-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-22885-8

Internet

https://doi.org/10.1038/s41598-022-22885-8

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