Impact of SARS-CoV-2 RBD Mutations on the Production of a Recombinant RBD Fusion Protein in Mammalian Cells

Impact of SARS-CoV-2 RBD Mutations on the Production of a Recombinant RBD Fusion Protein in Mammalian Cells

SARS-CoV-2 receptor-binding domain (RBD) is a major target for the development of diagnostics, vaccines and therapeutics directed against COVID-19. Important efforts have been dedicated to the rapid and efficient production of recombinant RBD proteins for clinical and diagnostic applications. One of...

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Bibliographic Details
Main Authors: Guillaume Gerez, Jerome Martinez, Christophe Steinbrugger, Sandra Bouanich, Johanna Dimino, Corine Piegay, Maxime Combe, Franck Berthier, Soizic Daniel
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Biomolecules
Subjects:
SARS-CoV-2
RBD
E484K mutation
disulphide bond
chaperone
protein disulphide isomerase
Online Access:https://www.mdpi.com/2218-273X/12/9/1170

Internet

https://www.mdpi.com/2218-273X/12/9/1170

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