Evaluating Known Zika Virus NS2B-NS3 Protease Inhibitor Scaffolds via In Silico Screening and Biochemical Assays

Evaluating Known Zika Virus NS2B-NS3 Protease Inhibitor Scaffolds via In Silico Screening and Biochemical Assays

The NS2B-NS3 protease (NS2B-NS3pro) is regarded as an interesting molecular target for drug design, discovery, and development because of its essential role in the Zika virus (ZIKV) cycle. Although no NS2B-NS3pro inhibitors have reached clinical trials, the employment of drug-like scaffolds can faci...

Full description

Bibliographic Details
Main Authors: Lucianna H. Santos, Rafael E. O. Rocha, Diego L. Dias, Beatriz M. R. M. Ribeiro, Mateus Sá M. Serafim, Jônatas S. Abrahão, Rafaela S. Ferreira
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Pharmaceuticals
Subjects:
biochemical assays
NS2B-NS3 protease
scaffold similarity
virtual screening
Zika virus
Online Access:https://www.mdpi.com/1424-8247/16/9/1319

Internet

https://www.mdpi.com/1424-8247/16/9/1319

Similar Items