Effects of thermal treatment on quality of biosimilar and originator monoclonal antibodies

Effects of thermal treatment on quality of biosimilar and originator monoclonal antibodies

Investigating products under stress conditions provides valuable information for assessing stability, biosimilarity, and degradation behaviors during monoclonal antibody (mAb) development. Proper sample preparation is crucial for accurately evaluating the biosimilarity and effects of stress conditio...

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Bibliographic Details
Main Authors: Yiğit Erdemgil, Merve Çelik Yamacı, Ceren Pamukcu, Fulya Ünalp, Zeynep Zülfiye Yıldırım Keleş, Ahmet Emin Atik, Muhittin Abdulkadir Serdar
Format: Article
Language:English
Published: Elsevier 2024-05-01
Series:Advances in Sample Preparation
Subjects:
mAb
Biosimilar
Thermal treatment
Impurity analysis
Fab binding activity
Post-translational modifications
Online Access:http://www.sciencedirect.com/science/article/pii/S2772582024000081

Internet

http://www.sciencedirect.com/science/article/pii/S2772582024000081

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