Tuning Design Parameters of ICAM-1-Targeted 3DNA Nanocarriers to Optimize Pulmonary Targeting Depending on Drug Type

Tuning Design Parameters of ICAM-1-Targeted 3DNA Nanocarriers to Optimize Pulmonary Targeting Depending on Drug Type

3DNA holds promise as a carrier for drugs that can be intercalated into its core or linked to surface arms. Coupling 3DNA to an antibody targeting intercellular adhesion molecule 1 (ICAM-1) results in high lung-specific biodistributions in vivo. While the role of individual parameters on ICAM-1 targ...

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Bibliographic Details
Main Authors: Nikša Roki, Melani Solomon, Jessica Bowers, Lori Getts, Robert C. Getts, Silvia Muro
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Pharmaceutics
Subjects:
3DNA nanocarrier
ICAM-1
lung targeting
carrier design parameters
multiparametric hierarchy
drug type
Online Access:https://www.mdpi.com/1999-4923/14/7/1496

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https://www.mdpi.com/1999-4923/14/7/1496

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