MUC1 Expression Affects the Immunoflogosis in Renal Cell Carcinoma Microenvironment through Complement System Activation and Immune Infiltrate Modulation

MUC1 Expression Affects the Immunoflogosis in Renal Cell Carcinoma Microenvironment through Complement System Activation and Immune Infiltrate Modulation

Mucin1 (MUC1), a glycoprotein associated with an aggressive cancer phenotype and chemoresistance, is aberrantly overexpressed in a subset of clear cell renal cell carcinoma (ccRCC). Recent studies suggest that MUC1 plays a role in modulating cancer cell metabolism, but its role in regulating immunof...

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Bibliographic Details
Main Authors: Giuseppe Lucarelli, Giuseppe Stefano Netti, Monica Rutigliano, Francesco Lasorsa, Davide Loizzo, Martina Milella, Annalisa Schirinzi, Antonietta Fontana, Francesca Di Serio, Roberto Tamma, Domenico Ribatti, Michele Battaglia, Elena Ranieri, Pasquale Ditonno
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:International Journal of Molecular Sciences
Subjects:
renal cell carcinoma
MUC1
PTX3
CA15-3
kynurenine
complement
Online Access:https://www.mdpi.com/1422-0067/24/5/4814

Internet

https://www.mdpi.com/1422-0067/24/5/4814

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