Conditional deletion of LRRC8A in the brain reduces stroke damage independently of swelling-activated glutamate release

Conditional deletion of LRRC8A in the brain reduces stroke damage independently of swelling-activated glutamate release

Summary: The ubiquitous volume-regulated anion channels (VRACs) facilitate cell volume control and contribute to many other physiological processes. Treatment with non-specific VRAC blockers or brain-specific deletion of the essential VRAC subunit LRRC8A is highly protective in rodent models of stro...

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Bibliographic Details
Main Authors: Mustafa Balkaya, Preeti Dohare, Sophie Chen, Alexandra L. Schober, Antonio M. Fidaleo, Julia W. Nalwalk, Rajan Sah, Alexander A. Mongin
Format: Article
Language:English
Published: Elsevier 2023-05-01
Series:iScience
Subjects:
Molecular biology
Molecular neuroscience
Cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223007460

Internet

http://www.sciencedirect.com/science/article/pii/S2589004223007460

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