The Effect of cAMP-PKA Activation on TGF-β1-Induced Profibrotic Signaling

The Effect of cAMP-PKA Activation on TGF-β1-Induced Profibrotic Signaling

Background: The cAMP-PKA signaling pathway and TGF-β1-dependent fibrosis pathways are of particular importance in ADPKD progression, but the cross-talk between these pathways remains unclear. Therefore, we used an MDCK-cell model and embryonic kidney-cyst model to study the regulatory role of cAMP-P...

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Bibliographic Details
Main Authors: Lin Weng, Weiling Wang, Xiaohong Su, Yong Huang, Limin Su, Ming Liu, Yi Sun, Baoxue Yang, Hong Zhou
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2015-07-01
Series:Cellular Physiology and Biochemistry
Subjects:
Autosomal dominant polycystic kidney disease (ADPKD)
Chronic kidney disease (CKD)
cAMP-PKA signaling pathway
Transforming growth factor-β1 (TGF-β1)
Extracellular regulated protein kinase (ERK)
Online Access:http://www.karger.com/Article/FullText/430160

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http://www.karger.com/Article/FullText/430160

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