Prospective study in a porcine model of sarcoptes scabiei indicates the association of Th2 and Th17 pathways with the clinical severity of scabies.

BACKGROUND:Understanding of scabies immunopathology has been hampered by the inability to undertake longitudinal studies in humans. Pigs are a useful animal model for scabies, and show clinical and immunologic changes similar to those in humans. Crusted scabies can be readily established in pigs by...

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Bibliographic Details
Main Authors: Kate E Mounsey, Hugh C Murray, Helle Bielefeldt-Ohmann, Cielo Pasay, Deborah C Holt, Bart J Currie, Shelley F Walton, James S McCarthy
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-03-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC4346266?pdf=render