Urotensin II Induces Mice Skeletal Muscle Atrophy Associated with Enhanced Autophagy and Inhibited Irisin Precursor (Fibronectin Type III Domain Containing 5) Expression in Chronic Renal Failure

Urotensin II Induces Mice Skeletal Muscle Atrophy Associated with Enhanced Autophagy and Inhibited Irisin Precursor (Fibronectin Type III Domain Containing 5) Expression in Chronic Renal Failure

Background/Aims: Skeletal muscle atrophy is one of the main manifestations of protein energy wasting. We hypothesized that urotensin II (UII) can lead to skeletal muscle atrophy through upregulating autophagy and affecting Irisin precursor fibronectin type III domain containing 5 (FNDC5) expressions...

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Bibliographic Details
Main Authors: Ya-Jing Pan, Si-Jia Zhou, Jin Feng, Qiong Bai, La-Ta A, Ai-Hua Zhang
Format: Article
Language:English
Published: Karger Publishers 2019-06-01
Series:Kidney & Blood Pressure Research
Subjects:
Urotensin II
Autophagy
Skeletal muscle cell
Irisin
Online Access:https://www.karger.com/Article/FullText/499880

Internet

https://www.karger.com/Article/FullText/499880

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