HSV neutralization by the microbicidal candidate C5A.

Genital herpes is a major risk factor in acquiring human immunodeficiency virus type-1 (HIV-1) infection and is caused by both Herpes Simplex virus type 1 (HSV-1) and HSV-2. The amphipathic peptide C5A, derived from the non-structural hepatitis C virus (HCV) protein 5A, was shown to prevent HIV-1 in...

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Bibliographic Details
Main Authors: Lot de Witte, Michael D Bobardt, Udayan Chatterji, Freek B van Loenen, Georges M G M Verjans, Teunis B H Geijtenbeek, Philippe A Gallay
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-05-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3089603?pdf=render