Identifying novel proteins underlying schizophrenia via integrating pQTLs of the plasma, CSF, and brain with GWAS summary data

Identifying novel proteins underlying schizophrenia via integrating pQTLs of the plasma, CSF, and brain with GWAS summary data

Abstract Background Schizophrenia (SCZ) is a chronic and severe mental illness with no cure so far. Mendelian randomization (MR) is a genetic method widely used to explore etiologies of complex traits. In the current study, we aimed to identify novel proteins underlying SCZ with a systematic analyti...

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Bibliographic Details
Main Authors: Xiaojing Gu, Meng Dou, Weiming Su, Zheng Jiang, Qingqing Duan, Bei Cao, Yongping Chen
Format: Article
Language:English
Published: BMC 2022-12-01
Series:BMC Medicine
Subjects:
Protein quantitative trait loci
Schizophrenia
Mendelian randomization
Complement 4
Neuroinflammation
Online Access:https://doi.org/10.1186/s12916-022-02679-5

Internet

https://doi.org/10.1186/s12916-022-02679-5

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