Different Patterns of Neurodegeneration and Glia Activation in CA1 and CA3 Hippocampal Regions of TgCRND8 Mice

Different Patterns of Neurodegeneration and Glia Activation in CA1 and CA3 Hippocampal Regions of TgCRND8 Mice

We investigated the different patterns of neurodegeneration and glia activation in CA1 and CA3 hippocampal areas of TgCRND8 mice. The main feature of this transgenic model is the rapid development of the amyloid pathology, which starts already at 3 months of age. We performed immunohistochemical ana...

Full description

Bibliographic Details
Main Authors: Filippo Ugolini, Daniele Lana, Pamela Nardiello, Daniele Nosi, Daniela Pantano, Fiorella Casamenti, Maria Grazia Giovannini
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Aging Neuroscience
Subjects:
Alzheimer’s disease
microglia
astrocytes
TNF-α
IL1β
iNOS
Online Access:https://www.frontiersin.org/article/10.3389/fnagi.2018.00372/full

Internet

https://www.frontiersin.org/article/10.3389/fnagi.2018.00372/full

Similar Items