Remodeling of the endothelial cell transcriptional program via paracrine and DNA-binding activities of MPO

Remodeling of the endothelial cell transcriptional program via paracrine and DNA-binding activities of MPO

Summary: Myeloperoxidase (MPO) is an enzyme that functions in host defense. MPO is released into the vascular lumen by neutrophils during inflammation and may adhere and subsequently penetrate endothelial cells (ECs) coating vascular walls. We show that MPO enters the nucleus of ECs and binds chroma...

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Bibliographic Details
Main Authors: Ruiyuan Zheng, Kyle Moynahan, Theodoros Georgomanolis, Egor Pavlenko, Simon Geissen, Athanasia Mizi, Simon Grimm, Harshal Nemade, Rizwan Rehimi, Jil Bastigkeit, Jan-Wilm Lackmann, Matti Adam, Alvaro Rada-Iglesias, Peter Nuernberg, Anna Klinke, Simon Poepsel, Stephan Baldus, Argyris Papantonis, Yulia Kargapolova
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:iScience
Subjects:
Molecular mechanism of gene regulation
Immunology
Cell biology
Proteomics
Transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224001196

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http://www.sciencedirect.com/science/article/pii/S2589004224001196

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