Granulocytic myeloid-derived suppressor cells increase infection risk via the IDO/IL-10 pathway in patients with hepatitis B virus-related liver failure

Granulocytic myeloid-derived suppressor cells increase infection risk via the IDO/IL-10 pathway in patients with hepatitis B virus-related liver failure

Hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) results in high susceptibility to infection. Although granulocytic myeloid-derived suppressor cells (gMDSC) are elevated in patients with HBV-ACLF, their role in HBV-ACLF pathogenesis is unknown. To elucidate the mechanism of gMDSC...

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Bibliographic Details
Main Authors: Xueping Yu, Jian Sun, Feifei Yang, Richeng Mao, Zhiqing Shen, Lan Ren, Songhua Yuan, Qian He, Linxia Zhang, Yu Yang, Xiangqing Ding, Yongquan He, Haoxiang Zhu, Zhongliang Shen, Mengqi Zhu, Chao Qiu, Zhijun Su, Jiming Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Immunology
Subjects:
hepatitis B virus
acute-on-chronic liver failure
granulocytic myeloid-derived suppressor cells
T cells
indoleamine 2
3-dioxygenase
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.966514/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.966514/full

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