Thrombopoietin knock-in augments platelet generation from human embryonic stem cells

Thrombopoietin knock-in augments platelet generation from human embryonic stem cells

Abstract Background Refinement of therapeutic-scale platelet production in vitro will provide a new source for transfusion in patients undergoing chemotherapy or radiotherapy. However, procedures for cost-effective and scalable platelet generation remain to be established. Methods In this study, we...

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Bibliographic Details
Main Authors: Leisheng Zhang, Cuicui Liu, Hongtao Wang, Dan Wu, Pei Su, Mengge Wang, Jiaojiao Guo, Shixuan Zhao, Shuxu Dong, Wen Zhou, Cameron Arakaki, Xiaobing Zhang, Jiaxi Zhou
Format: Article
Language:English
Published: BMC 2018-07-01
Series:Stem Cell Research & Therapy
Subjects:
Thrombopoietin
Knock-in
Early hematopoiesis
Platelets
Human embryonic stem cells
Online Access:http://link.springer.com/article/10.1186/s13287-018-0926-x

Internet

http://link.springer.com/article/10.1186/s13287-018-0926-x

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