Characterizing Features of Human Circulating B Cells Carrying CLL-Like Stereotyped Immunoglobulin Rearrangements

Characterizing Features of Human Circulating B Cells Carrying CLL-Like Stereotyped Immunoglobulin Rearrangements

Chronic Lymphocytic Leukemia (CLL) is characterized by the accumulation of monoclonal CD5+ B cells with low surface immunoglobulins (IG). About 40% of CLL clones utilize quasi-identical B cell receptors, defined as stereotyped BCR. CLL-like stereotyped-IG rearrangements are present in normal B cells...

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Bibliographic Details
Main Authors: Davide Bagnara, Monica Colombo, Daniele Reverberi, Serena Matis, Rosanna Massara, Niccolò Cardente, Gianluca Ubezio, Vanessa Agostini, Luca Agnelli, Antonino Neri, Martina Cardillo, Stefano Vergani, Fabio Ghiotto, Andrea Nicola Mazzarello, Fortunato Morabito, Giovanna Cutrona, Manlio Ferrarini, Franco Fais
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Oncology
Subjects:
chronic lymphocytic leukemia (CLL)
immunoglobulin repertoire
B-cells
CD5
IGHV somatic mutations
Ig light chain
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.894419/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2022.894419/full

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