Paradoxical Inhibition of Glycolysis by Pioglitazone Opposes the Mitochondriopathy Caused by AIF Deficiency

Paradoxical Inhibition of Glycolysis by Pioglitazone Opposes the Mitochondriopathy Caused by AIF Deficiency

Mice with the hypomorphic AIF-Harlequin mutation exhibit a highly heterogeneous mitochondriopathy that mostly affects respiratory chain complex I, causing a cerebral pathology that resembles that found in patients with AIF loss-of-function mutations. Here we describe that the antidiabetic drug piogl...

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Bibliographic Details
Main Authors: Paule Bénit, Alice Pelhaître, Elise Saunier, Sylvie Bortoli, Assetou Coulibaly, Malgorzata Rak, Manuel Schiff, Guido Kroemer, Massimo Zeviani, Pierre Rustin
Format: Article
Language:English
Published: Elsevier 2017-03-01
Series:EBioMedicine
Subjects:
AIFM1
X-linked mitochondrial encephalomyelopathy
Pre-clinical trial
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)
Bezafibrate
Melatonin
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396417300725

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http://www.sciencedirect.com/science/article/pii/S2352396417300725

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