Cytochrome P450 enzymes: understanding the biochemical hieroglyphs [v1; ref status: indexed, http://f1000r.es/583]
Cytochrome P450 (CYP) enzymes are the primary proteins of drug metabolism and steroid biosynthesis. These crucial proteins have long been known to harbor a cysteine thiolate bound to the heme iron. Recent advances in the field have illuminated the nature of reactive intermediates in the reaction cyc...
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| Format: | Article |
| Language: | English |
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F1000 Research Ltd
2015-07-01
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| Series: | F1000Research |
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| Online Access: | http://f1000research.com/articles/4-178/v1 |
| _version_ | 1818994006419308544 |
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| author | John T. Groves |
| author_facet | John T. Groves |
| author_sort | John T. Groves |
| collection | DOAJ |
| description | Cytochrome P450 (CYP) enzymes are the primary proteins of drug metabolism and steroid biosynthesis. These crucial proteins have long been known to harbor a cysteine thiolate bound to the heme iron. Recent advances in the field have illuminated the nature of reactive intermediates in the reaction cycle. Similar intermediates have been observed and characterized in novel heme-thiolate proteins of fungal origin. Insights from these discoveries have begun to solve the riddle of how enzyme biocatalyst design can afford a protein that can transform substrates that are more difficult to oxidize than the surrounding protein architecture. |
| first_indexed | 2024-12-20T20:51:05Z |
| format | Article |
| id | doaj.art-dfeb1f3d53e54769a9bc06997f9f224a |
| institution | Directory Open Access Journal |
| issn | 2046-1402 |
| language | English |
| last_indexed | 2024-12-20T20:51:05Z |
| publishDate | 2015-07-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | F1000Research |
| spelling | doaj.art-dfeb1f3d53e54769a9bc06997f9f224a2022-12-21T19:26:55ZengF1000 Research LtdF1000Research2046-14022015-07-01410.12688/f1000research.6314.16771Cytochrome P450 enzymes: understanding the biochemical hieroglyphs [v1; ref status: indexed, http://f1000r.es/583]John T. Groves0Department of Chemistry, Princeton University, Princeton, NJ, 08544, USACytochrome P450 (CYP) enzymes are the primary proteins of drug metabolism and steroid biosynthesis. These crucial proteins have long been known to harbor a cysteine thiolate bound to the heme iron. Recent advances in the field have illuminated the nature of reactive intermediates in the reaction cycle. Similar intermediates have been observed and characterized in novel heme-thiolate proteins of fungal origin. Insights from these discoveries have begun to solve the riddle of how enzyme biocatalyst design can afford a protein that can transform substrates that are more difficult to oxidize than the surrounding protein architecture.http://f1000research.com/articles/4-178/v1BiocatalysisBioinorganic ChemistryBiomacromolecule-Ligand InteractionsCancer TherapeuticsChemical Biology of the CellDrug Discovery & DesignExperimental Biophysical MethodsProtein Chemistry & Proteomics |
| spellingShingle | John T. Groves Cytochrome P450 enzymes: understanding the biochemical hieroglyphs [v1; ref status: indexed, http://f1000r.es/583] F1000Research Biocatalysis Bioinorganic Chemistry Biomacromolecule-Ligand Interactions Cancer Therapeutics Chemical Biology of the Cell Drug Discovery & Design Experimental Biophysical Methods Protein Chemistry & Proteomics |
| title | Cytochrome P450 enzymes: understanding the biochemical hieroglyphs [v1; ref status: indexed, http://f1000r.es/583] |
| title_full | Cytochrome P450 enzymes: understanding the biochemical hieroglyphs [v1; ref status: indexed, http://f1000r.es/583] |
| title_fullStr | Cytochrome P450 enzymes: understanding the biochemical hieroglyphs [v1; ref status: indexed, http://f1000r.es/583] |
| title_full_unstemmed | Cytochrome P450 enzymes: understanding the biochemical hieroglyphs [v1; ref status: indexed, http://f1000r.es/583] |
| title_short | Cytochrome P450 enzymes: understanding the biochemical hieroglyphs [v1; ref status: indexed, http://f1000r.es/583] |
| title_sort | cytochrome p450 enzymes understanding the biochemical hieroglyphs v1 ref status indexed http f1000r es 583 |
| topic | Biocatalysis Bioinorganic Chemistry Biomacromolecule-Ligand Interactions Cancer Therapeutics Chemical Biology of the Cell Drug Discovery & Design Experimental Biophysical Methods Protein Chemistry & Proteomics |
| url | http://f1000research.com/articles/4-178/v1 |
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