Ribosomal Dysfunction Is a Common Pathomechanism in Different Forms of Trichothiodystrophy

Ribosomal Dysfunction Is a Common Pathomechanism in Different Forms of Trichothiodystrophy

Mutations in a broad variety of genes can provoke the severe childhood disorder trichothiodystrophy (TTD) that is classified as a DNA repair disease or a transcription syndrome of RNA polymerase II. In an attempt to identify the common underlying pathomechanism of TTD we performed a knockout/knockdo...

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Bibliographic Details
Main Authors: Gaojie Zhu, Fatima Khalid, Danhui Zhang, Zhouli Cao, Pallab Maity, Hans A. Kestler, Donata Orioli, Karin Scharffetter-Kochanek, Sebastian Iben
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Cells
Subjects:
ribosome
trichothiodystrophy
translational infidelity
loss of proteostasis
Online Access:https://www.mdpi.com/2073-4409/12/14/1877

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https://www.mdpi.com/2073-4409/12/14/1877

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