Neuroglobin-deficiency exacerbates Hif1A and c-FOS response, but does not affect neuronal survival during severe hypoxia in vivo.

Neuroglobin-deficiency exacerbates Hif1A and c-FOS response, but does not affect neuronal survival during severe hypoxia in vivo.

Neuroglobin (Ngb), a neuron-specific globin that binds oxygen in vitro, has been proposed to play a key role in neuronal survival following hypoxic and ischemic insults in the brain. Here we address whether Ngb is required for neuronal survival following acute and prolonged hypoxia in mice genetical...

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Bibliographic Details
Main Authors: Christian Ansgar Hundahl, Hendrik Luuk, Sten Ilmjärv, Birgitte Falktoft, Zindy Raida, Jonas Vikesaa, Lennart Friis-Hansen, Anders Hay-Schmidt
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3229544?pdf=render

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http://europepmc.org/articles/PMC3229544?pdf=render

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