Interleukin-7 Induces Osteoclast Formation via STAT5, Independent of Receptor Activator of NF-kappaB Ligand

Interleukin-7 Induces Osteoclast Formation via STAT5, Independent of Receptor Activator of NF-kappaB Ligand

Interleukin-7 (IL-7), which is required for the development and survival of T cells in the thymus and periphery, plays a role in joint destruction. However, it remains unclear how IL-7 affects osteoclast formation. Thus, we investigated the mechanism by which IL-7 induced osteoclast formation throug...

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Bibliographic Details
Main Authors: Jin-Hee Kim, Ji Hyun Sim, Sunkyung Lee, Min A. Seol, Sang-Kyu Ye, Hyun Mu Shin, Eun Bong Lee, Yun Jong Lee, Yun Jung Choi, Wan-Hee Yoo, Jin Hyun Kim, Wan-Uk Kim, Dong-Sup Lee, Jin-Hong Kim, Insoo Kang, Seong Wook Kang, Hang-Rae Kim
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-10-01
Series:Frontiers in Immunology
Subjects:
osteoclast
intereleukin-7
IL-7 receptor alpha
STAT5
RANKL
monocyte
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01376/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01376/full

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