Reversal of angiotensin ll-induced β-cell dedifferentiation via inhibition of NF-κb signaling

Reversal of angiotensin ll-induced β-cell dedifferentiation via inhibition of NF-κb signaling

Abstract Background Type 2 diabetes mellitus (T2DM) is characterized by pancreatic β-cell failure, which arises from metabolic stress and results in β cell dedifferentiation, leading to β-cell death. Pathological activation of the renin–angiotensin system (RAS) contributes to increase cell stress, w...

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Prif Awduron: Hong Chen, Wenjun Zhou, Yuting Ruan, Lei Yang, Ningning Xu, Rongping Chen, Rui Yang, Jia Sun, Zhen Zhang
Fformat: Erthygl
Iaith:English
Cyhoeddwyd: BMC 2018-08-01
Cyfres:Molecular Medicine
Pynciau:
β-Cell dedifferentiation
Renin-angiotensin system
Angiotensin ll
Type 2 diabetes
NF-κb
Mynediad Ar-lein:http://link.springer.com/article/10.1186/s10020-018-0044-3

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http://link.springer.com/article/10.1186/s10020-018-0044-3

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