Propionate, rather than acetate or butyrate, ameliorates methamphetamine-induced hepatotoxicity and enterotoxicity in mice by downregulating the TLR4/NF-κB pathway

Propionate, rather than acetate or butyrate, ameliorates methamphetamine-induced hepatotoxicity and enterotoxicity in mice by downregulating the TLR4/NF-κB pathway

The abuse of methamphetamine (METH) has emerged as a major public health concern, causing liver and intestinal damage upon exposure. Short chain fatty acids (SCFAs) produced by dietary fiber, including acetate, propionate, and butyrate, have been reported to alleviate various liver toxicities and ex...

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Bibliographic Details
Main Authors: Li-Jian Chen, Xiu-Wen Li, Yi Liu, Jia-Li Liu, Jian-Zheng Yang, Jia-Hao Li, Clare Hsu, Long Chen, Jia-Hao Zeng, Xiao-Li Xie, Qi Wang
Format: Article
Language:English
Published: Elsevier 2023-10-01
Series:Journal of Functional Foods
Subjects:
Methamphetamine
Propionate
Hepatotoxicity
Enterotoxicity
Lipopolysaccharide
TLR4/MyD88/NF-κB
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464623003961

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http://www.sciencedirect.com/science/article/pii/S1756464623003961

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