A partitioned 88-loci psoriasis genetic risk score reveals HLA and non-HLA contributions to clinical phenotypes in a Newfoundland psoriasis cohort

A partitioned 88-loci psoriasis genetic risk score reveals HLA and non-HLA contributions to clinical phenotypes in a Newfoundland psoriasis cohort

Psoriasis is an immune-mediated inflammatory skin disease typically characterized by erythematous and scaly plaques. It affects 3% of the Newfoundland population while only affecting 1.7% of the general Canadian population. Recent genome-wide association studies (GWAS) in psoriasis have identified m...

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Bibliographic Details
Main Authors: Audrey Bui, Sugandh Kumar, Jared Liu, Faye Orcales, Susanne Gulliver, Lam C. Tsoi, Wayne Gulliver, Wilson Liao
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Genetics
Subjects:
genetic risk score (GRS)
polygenic risk score (PRS)
psoriasis
Newfoundland and labrador
genetics
HLA
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2023.1141010/full

Internet

https://www.frontiersin.org/articles/10.3389/fgene.2023.1141010/full

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