New Panx-1 Blockers: Synthesis, Biological Evaluation and Molecular Dynamic Studies

New Panx-1 Blockers: Synthesis, Biological Evaluation and Molecular Dynamic Studies

The channel protein Panx-1 is involved in some pathologies, such as epilepsy, ischemic stroke, cancer and Parkinson’s disease, as well as in neuropathic pain. These observations make Panx-1 an interesting biological target. We previously published some potent indole derivatives as Panx-1 blockers, a...

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Bibliographic Details
Main Authors: Letizia Crocetti, Gabriella Guerrini, Maria Paola Giovannoni, Fabrizio Melani, Silvia Lamanna, Lorenzo Di Cesare Mannelli, Elena Lucarini, Carla Ghelardini, Junjie Wang, Gerhard Dahl
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:International Journal of Molecular Sciences
Subjects:
pannexin
panx-1 blockers
organic synthesis
electrophysiological assay
neuropathic pain
proximity frequencies
Online Access:https://www.mdpi.com/1422-0067/23/9/4827

Internet

https://www.mdpi.com/1422-0067/23/9/4827

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