CaMKII-Dependent Contractile Dysfunction and Pro-Arrhythmic Activity in a Mouse Model of Obstructive Sleep Apnea

CaMKII-Dependent Contractile Dysfunction and Pro-Arrhythmic Activity in a Mouse Model of Obstructive Sleep Apnea

Left ventricular contractile dysfunction and arrhythmias frequently occur in patients with sleep-disordered breathing (SDB). The CaMKII-dependent dysregulation of cellular Ca homeostasis has recently been described in SDB patients, but these studies only partly explain the mechanism and are limited...

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Bibliographic Details
Main Authors: Philipp Hegner, Simon Lebek, Benedikt Schaner, Florian Ofner, Mathias Gugg, Lars Siegfried Maier, Michael Arzt, Stefan Wagner
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Antioxidants
Subjects:
obstructive sleep apnea
oxidative stress
CaMKII
contractile dysfunction
arrhythmias
Online Access:https://www.mdpi.com/2076-3921/12/2/315

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https://www.mdpi.com/2076-3921/12/2/315

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