Inhibition of Bcl-xL sensitizes cells to mitotic blockers, but not mitotic drivers
Cell fate in response to an aberrant mitosis is governed by two competing networks: the spindle assembly checkpoint (SAC) and the intrinsic apoptosis pathway. The mechanistic interplay between these two networks is obscured by functional redundancy and the ability of cells to die either in mitosis o...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
The Royal Society
2016-01-01
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| Series: | Open Biology |
| Subjects: | |
| Online Access: | https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.160134 |