Distinct VSV-based Nipah virus vaccines expressing either glycoprotein G or fusion protein F provide homologous and heterologous protection in a nonhuman primate modelResearch in context

Distinct VSV-based Nipah virus vaccines expressing either glycoprotein G or fusion protein F provide homologous and heterologous protection in a nonhuman primate modelResearch in context

Summary: Background: Nipah virus (NiV) causes recurrent outbreaks of lethal respiratory and neurological disease in Southeast Asia. The World Health Organization considers the development of an effective vaccine against NiV a priority. Methods: We produced two NiV vaccine candidates using the licen...

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Bibliographic Details
Main Authors: Emmie de Wit, Friederike Feldmann, Jacqueline Cronin, Kerry Goldin, Reinaldo Mercado-Hernandez, Brandi N. Williamson, Kimberly Meade-White, Atsushi Okumura, Julie Callison, Sarah Weatherman, Rebecca Rosenke, Victoria A. Avanzato, Jamie Lovaglio, Dana P. Scott, Andrea Marzi, Heinz Feldmann
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:EBioMedicine
Subjects:
Nipah virus
VSV-based vaccines
African green monkey
Vaccine efficacy
Heterologous protection
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396422005874

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http://www.sciencedirect.com/science/article/pii/S2352396422005874

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