3D Reconstruction of the Neurovascular Unit Reveals Differential Loss of Cholinergic Innervation in the Cortex and Hippocampus of the Adult Mouse Brain

3D Reconstruction of the Neurovascular Unit Reveals Differential Loss of Cholinergic Innervation in the Cortex and Hippocampus of the Adult Mouse Brain

Increasing evidence supports a role for cerebrovasculature dysfunction in the etiology of Alzheimer’s disease (AD). Blood vessels in the brain are composed of a collection of cells and acellular material that comprise the neurovascular unit (NVU). The NVU in the hippocampus and cortex receives inner...

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Bibliographic Details
Main Authors: Shereen Nizari, Roxana O. Carare, Ignacio A. Romero, Cheryl A. Hawkes
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Aging Neuroscience
Subjects:
neurovascular unit
cholinergic
Alzheimer’s disease
cerebral amyloid angiopathy
cortex
hippocampus
Online Access:https://www.frontiersin.org/article/10.3389/fnagi.2019.00172/full

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https://www.frontiersin.org/article/10.3389/fnagi.2019.00172/full

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